Product Evidence
We value your trust, and we want you to understand the research and rationale behind our products and their ingredients.
The following is an overview of the active ingredients in Wave Bye products, the effects of those ingredients, and the evidence that has been produced to support each effect. This evidence has guided our product development and our claims for action against period pain and symptoms.
†Disclaimer: There is Level 1A medical evidence that Naproxen reduces menstrual pain and bleeding when taken before period bleeding onset.
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Research-Backed Evidence for Active Ingredients
Bye Cramps
A Randomised Placebo-Controlled Trial To Determine The Effect Of Vitamin E In Treatment Of Primary Dysmenorrhoea
Authors: S Ziaei, S Faghihzadeh, F Sohrabvand, M Lamyian, T Emamgholy
Excerpt: "Both placebo and vitamin E are effective in relieving symptoms due to primary dysmenorrhoea, but the effects of vitamin E are more marked."
A Randomised Controlled Trial Of Vitamin E In The Treatment Of Primary Dysmenorrhoea
Authors: S Ziaei, M Zakeri, A Kazemnejad
Excerpt: "Vitamin E relieves the pain of primary dysmenorrhoea and reduces blood loss."
The Effects of Vitamin B1 on Ameliorating the Premenstrual Syndrome Symptoms
Authors: Sareh Abdollahifard, Afifeh Rahmanian Koshkaki, Reza Moazamiyanfar
Excerpt: "It seems that vitamin B1 is effective in recovery of mental and physical symptoms of PMS. Therefore, this vitamin can be used to reach a major goal of midwifery, that is, reduction of symptom severity of PMS, without any side effects."
Efficacy of Vitamin B6 in the Treatment of Premenstrual Syndrome: Systematic Review
Authors: Katrina M Wyatt, Paul W Dimmock, Peter W Jones, P M Shaughn O'Brien
Excerpt: "Results suggest that doses of vitamin B-6 up to 100 mg/day are likely to be of benefit in treating premenstrual symptoms and premenstrual depression."
Bye Bad Cramps
Diagnosis and Initial Management of Dysmenorrhea
Authors: Amimi S. Osayande, MD, and Suarna Mehulic, MD
Excerpt: "The best treatment of primary dysmenorrhea is NSAIDs started 1-2 days before the onset of menses, continued on a fixed schedule for 2-3 days. Complementary treatments include heat, exercise and supplements (such as omega-3 fatty acids and vitamin B)."
Nonsteroidal Anti-Inflammatory Drugs For Dysmenorrhoea
Authors: Jane Marjoribanks, Reuben Olugbenga Ayeleke, Cindy Farquhar, Michelle Proctor
Excerpt: "Around 75% of people who menstruate report pain. NSAIDs are very effective at reducing menstrual pain."
Non-steroidal Anti-inflammatory Drugs for Heavy Menstrual Bleeding
Authors: Magdalena Bofill Rodriguez, Anne Lethaby, Cindy Farquhar
Excerpt: "NSAIDs reduce heavy menstrual bleeding when compared with placebo, but are less effective than tranexamic acid, danazol or LNG IUS."
Bye Irregularity
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Dorina Greff, Anna E Juhász, Szilárd Váncsa, Alex Váradi, Zoltán Sipos, Julia Szinte, Sunjune Park, Péter Hegyi, Péter Nyirády, Nándor Ács, Szabolcs Várbíró, Eszter M Horváth
Excerpt: "Inositol is an effective and safe treatment in PCOS. Moreover, inositols showed non-inferiority in most outcomes compared to the gold standard treatment; metformin."
Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium
Author(s): F Facchinetti, G Sances, P Borella, A R Genazzani, G Nappi
Excerpt: "These data point to magnesium supplementation as a further means for menstrual migraine prophylaxis, and support the possibility that a lower migraine threshold could be related to magnesium deficiency."
The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations in adults and children: a systematic review and meta-analysis of randomized controlled trials
Authors: Jordie A J Fischer, Arlin M Cherian, Jeffrey N Bone, Crystal D Karakochuk
Excerpt: "Ferrous bisglycinate shows some benefit over other iron supplements in increasing hemoglobin concentration and reducing GI adverse events among pregnant women."
Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials
Authors: M Diana van Die, Henry G Burger, Helena J Teede, Kerry M Bone
Excerpt: "Despite some methodological limitations, the results from randomised, controlled trials to date suggest benefits for Vitex extracts in the treatment of premenstrual syndrome, premenstrual dysphoric disorder and latent hyperprolactinaemia."